Immunotherapy for Dogs: Running Behind Humans
نویسنده
چکیده
A number of excellent reviews on the potential of canine cancer immunotherapy are available, but many extrapolate from observations in humans when in fact only very few immunotherapies have been developed for canines that have shown efficacy in well-designed studies. Pharmaceutical and biotech companies are aware that the market for more expensive immunotherapies in canines is limited resulting in limited funding for clinical trials. However, dogs and other pets deserve access to this new form of cancer therapy. The purpose of this brief review is to summarize the current status of available immunotherapies for dogs and their near-term prospects, provided we can effectively translate discoveries and progress in humans to canines.
منابع مشابه
Sublingual Immunotherapy in Human and Canine Atopic Dermatitis: A Mini Review
Atopic Dermatitis (AD) is a prevalent disease that affects both humans and animals. Dogs share similar environments with the owners and spontaneously develop a disease that is clinically and immunologically identical to AD in humans. In past decades AD has become more and more common in both dogs and humans, possibly due to the increased exposure to indoor allergens and decreased exposure to pa...
متن کاملIdentification of myeloid derived suppressor cells in the peripheral blood of tumor bearing dogs
BACKGROUND Myeloid derived suppressor cells (MDSCs) are a recently described population of immune cells that significantly contribute to the immunosuppression seen in cancer patients. MDSCs are one of the most important factors that limit the efficacy of cancer immunotherapy (e.g. cancer vaccines) and MDSC levels are increased in cancer in multiple species. Identifying and targeting MDSCs is ac...
متن کاملEvolutionary approach to communication between humans and dogs
Dog-human communication has been widely investigated recently for different theoretical reasons, in most cases through dogs’ comprehension of human gestural cues. Dogs have been reported to be very skilful in comprehending a variety of human pointing gestures in many independent studies. This paper provides a short overview of the possible explanations behind the dogs’ exceptional communication...
متن کاملApplication of Recombinant Proteins for Serodiagnosis of Visceral Leishmaniasis in Humans and Dogs
Visceral leishmaniasis (VL) is a zoonotic disease caused by leishmania species. Dogs are considered to be the main reservoir of VL. A number of methods and antigen-based assays are used for the diagnosis of leishmaniasis. However, currently available methods are mainly based on direct examination of tissues for the presence of parasites, which is highly invasive. A variety of serological tests ...
متن کاملA review of allergen-specific immunotherapy in human and veterinary medicine.
This article reviews allergen-specific immunotherapy in human and veterinary medicine. Current hypotheses of possible mechanisms of actions are outlined. Indications, success rates, adverse effects and factors influencing outcome of therapy are discussed in humans, dogs, cats and horses.
متن کامل